RABBIT ANTI ROCK1

Rabbit anti Human ROCK1 antibody recognizes ROCK1, also known as P160ROCK and rho-associated protein kinase 1.

This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18 (provided by RefSeq, Aug 2015).

Rabbit anti Human ROCK1 antibody detects a band of 160 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.