RABBIT ANTI RPL13A

Rabbit anti Human RPL13A antibody recognizes the 60S ribosomal protein L13a, also known as 23 kDa highly basic protein or tissue specific transplantation antigen 1.

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. RPL13A encodes a member of the L13P family of ribosomal proteins that is a component of the 60S subunit. The encoded protein also plays a role in the repression of inflammatory genes as a component of the IFN-gamma-activated inhibitor of translation (GAIT) complex. RPL13A is co-transcribed with the small nucleolar RNA genes U32, U33, U34, and U35, which are located in the second, fourth, fifth, and sixth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of RPL13A dispersed throughout the genome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for RPL13A (provided by RefSeq, Jul 2012).

Rabbit anti Human RPL13A antibody detects a band of 23 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.