Rabbit anti Human RPL3 antibody recognizes the RPL3, also known as 60S ribosomal protein L3, ASC-1 and HIV-1 TAR RNA-binding protein B.
Ribosomes, the complexes that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. RPL3 encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L3P family of ribosomal proteins and it is located in the cytoplasm. The protein can bind to the HIV-1 TAR mRNA, and it has been suggested that the protein contributes to tat-mediated transactivation. RPL3 is co-transcribed with several small nucleolar RNA genes, which are located in several of RPL3's introns. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of RPL3 dispersed through the genome (provided by RefSeq, Jul 2008).
Rabbit anti Human RPL3 antibody detects a band of 46 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
