RABBIT ANTI RPS3

Rabbit anti Human RPS3 antibody recognizes RPS3, also known as 40S ribosomal protein S3 and IMR-90 ribosomal protein S3.

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. The RPS3 gene encodes a ribosomal protein that is a component of the 40S subunit, where it forms part of the domain where translation is initiated. The protein belongs to the S3P family of ribosomal proteins. Studies of the mouse and rat proteins have demonstrated that the protein has an extra-ribosomal role as an endonuclease involved in the repair of UV-induced DNA damage. The protein appears to be located in both the cytoplasm and nucleus but not in the nucleolus. Higher levels of expression of RPS3 in colon adenocarcinomas and adenomatous polyps compared to adjacent normal colonic mucosa have been observed. RPS3 is co-transcribed with the small nucleolar RNA genes U15A and U15B, which are located in its first and fifth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of RPS3 dispersed through the genome. Multiple alternatively spliced transcript variants encoding different isoforms have been found for RPS3 (provided by RefSeq, May 2012).

Rabbit anti Human RPS3 antibody detects a band of 27 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.