RABBIT ANTI S6

Rabbit anti Human S6 antibody recognizes the 26S protease regulatory subunit 6B, also known as 26S proteasome AAA-ATPase subunit RPT3, MB67-interacting protein, or Tat-binding protein 7 or PSMC4 protein.

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. PSMC4 gene encodes a member of the triple-A family of ATPases that is a component of the 19S regulatory subunit and plays a role in 26S proteasome assembly. The encoded protein interacts with gankyrin, a liver oncoprotein, and may also play a role in Parkinson's disease through interactions with synphilin-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for PSMC4 (provided by RefSeq, Jul 2012).

Rabbit anti Human S6 antibody detects a band of 47 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.