RABBIT ANTI SIRT1

Rabbit anti Human SIRT1 antibody recognizes SIRT1, also known as NAD-dependent deacetylase sirtuin-1, SIR2-like protein 1, SIR2alpha, hSIR2, hSIRT1, regulatory protein SIR2 homolog 1 and sirtuin type 1.

The SIRT1 gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by SIRT1 is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants (provided by RefSeq, Dec 2008).

Rabbit anti Human SIRT1 antibody detects a band of 120 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.