RABBIT ANTI STK24

Rabbit anti Human STK24 antibody recognizes the serine/threonine-protein kinase 24, also known as STE20-like kinase 3, serine/threonine-protein kinase 24 and sterile 20-like kinase 3.

The yeast 'Sterile 20' gene (STE20) functions upstream of the mitogen-activated protein kinase (MAPK) cascade. In mammals, protein kinases related to STE20 can be divided into 2 subfamilies based on their structure and regulation. Members of the PAK subfamily (see PAK3; MIM 300142) contain a C-terminal catalytic domain and an N-terminal regulatory domain that has a CDC42 (MIM 116952)-binding domain. In contrast, members of the GCK subfamily (see MAP4K2; MIM 603166), also called the Sps1 subfamily, have an N-terminal catalytic domain and a C-terminal regulatory domain without a CDC42-binding domain. STK24 belongs to the GCK subfamily of STE20-like kinases (Zhouet al., 2000 (PubMed 10644707)) (supplied by OMIM, Mar 2008).

Rabbit anti STK24 antibody detects a band of 60 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.