RABBIT ANTI TDP-43

Rabbit anti Human TDP-43 antibody recognizes TARDBP also known as ALS10 and TAR DNA-binding protein 43.

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20 (provided by RefSeq, Jul 2008).

Rabbit anti Human TDP-43 antibody detects a band of 45 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.