RABBIT ANTI TGFBI

Rabbit anti Human TGFBI antibody recognizes the transforming growth factor-beta-induced protein ig-h3, also known as RGD-containing collagen-associated protein (RGD-CAP), beta ig-h3, kerato-epithelin or transforming growth factor, beta-induced 68 kDa.

TGFBI gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in TGFBI are associated with multiple types of corneal dystrophy (provided by RefSeq, Jul 2008).

Rabbit anti Human TGFBI antibody detects a band of 70 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.