RABBIT ANTI TISSUE TRANSGLUTAMINASE

Rabbit anti Human tissue transglutaminase antibody recognizes tissue transglutaminase, also known as protein-glutamine gamma-glutamyltransferase 2, C polypeptide, TG(C), TGase C, TGase H, TGase-2, TGase-H, epididymis secretory protein Li 45, transglutaminase C, transglutaminase H and transglutaminase-2.

Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. Encoded by the TGM2 gene, tissue transglutaminase acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. It is also the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for TGM2 (provided by RefSeq, Jul 2008).

Rabbit anti Human tissue transglutaminase antibody detects a band of 78 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.