Rabbit anti Human tubulin alpha 3C/D chain antibody recognizes the tubulin alpha 3C/D chain, also known as alpha-tubulin 2, tubulin alpha-2 chain or tubulin alpha 2.
Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. TUBA3C is an alpha tubulin gene that encodes a protein 99% identical to the mouse testis-specific Tuba3 and Tuba7 gene products. TUBA3C gene is located in the 13q11 region, which is associated with the genetic diseases Clouston hidrotic ectodermal dysplasia and Kabuki syndrome (provided by RefSeq, Jul 2008).
Rabbit anti Human tubulin alpha 3C/D chain antibody detects a band of 50 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.>
