RABBIT ANTI U2AF2

Rabbit anti Human U2AF2 antibody recognizes the splicing factor U2AF 65 kDa subunit, also known as U2 (RNU2) small nuclear RNA auxiliary factor 2, U2 auxiliary factor 65 kDa subunit, U2 small nuclear ribonucleoprotein auxiliary factor (65kD), U2 snRNP auxiliary factor large subunit and hU2AF65.

Splicing factor U2AF is comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. U2AF2 gene encodes the large 65 kDa subunit which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of introns early during spliceosome assembly. Multiple transcript variants have been detected for U2AF2, but the full-length natures of only two have been determined to date (provided by RefSeq, Jul 2008).

Rabbit anti Human U2AF2 antibody detects a band of 65 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.