RABBIT ANTI UBE2D1

Rabbit anti Human UBE2D1 antibody recognizes UBE2D1, also known as UBC4/5 homolog, stimulator of Fe transport, ubiquitin carrier protein D1, ubiquitin-conjugating enzyme E2 D1, ubiquitin-conjugating enzyme E2-17 kDa 1 and ubiquitin-protein ligase D1.

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. The UBE2D1 gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. Two transcript variants encoding different isoforms have been found for UBE2D1 (provided by RefSeq, Mar 2011).

Rabbit anti Human UBE2D1 antibody detects a band of 17 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.