RABBIT ANTI UBE2D2

Rabbit anti Human UBE2D2 antibody recognizes UBE2D2, also known as p53-regulated ubiquitin-conjugating enzyme 1, ubiquitin carrier protein D2, ubiquitin-conjugating enzyme E2-17 kDa 2 and ubiquitin-protein ligase D2.

Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) enzymes. UBE2D2 encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of UBE2D2 (provided by RefSeq, May 2013).

Rabbit anti Human UBE2D2 antibody detects a band of 16 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.