RABBIT ANTI UBE2V1

Rabbit anti Human UBE2V1 antibody recognizes the ubiquitin-conjugating enzyme E2 variant 1 also known as CROC-1 or TRAF6-regulated IKK activator 1 beta Uev1A.

Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene is located in the nucleus and can cause transcriptional activation of the human FOS proto-oncogene. It is thought to be involved in the control of differentiation by altering cell cycle behavior. Alternatively spliced transcript variants encoding multiple isoforms have been described for this gene, and multiple pseudogenes of this gene have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (Kua-UEV), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product [provided by RefSeq, Apr 2012].

Rabbit anti Human UBE2V1 antibody detects a band of 16 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.