RABBIT ANTI UBIQUILIN-1

Rabbit anti Human ubiquilin-1 antibody recognizes ubiquilin-1, also known as hPLIC-1 or protein linking IAP with cytoskeleton 1.

The UBQLN1 gene encodes an ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and it is found in lesions associated with Alzheimer's and Parkinson's disease (Mah et al. 2000). Two transcript variants encoding different isoforms have been found for UBQLN1 (provided by RefSeq, Jul 2008).

Rabbit anti Human ubiquilin-1 antibody detects a band of 66 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.