RABBIT ANTI VINCULIN

Rabbit anti Human vinculin antibody recognizes vinculin, also known as metavinculin (MVCL).

Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for VCL, but the biological validity of some variants has not been determined (provided by RefSeq, Jul 2008).

Rabbit anti Human vinculin antibody detects a band of 124 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.