Rabbit anti Human VPS26A antibody recognizes VPS26A, also known as vacuolar protein sorting-associated protein 26A and vesicle protein sorting 26A.
VPS26A belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. Alternative splicing results in multiple transcript variants encoding different isoforms (provided by RefSeq, Jul 2008).
Rabbit anti Human VPS26A antibody detects a band of 38 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
