Suplementos y factores de crecimiento de medio H mM para mantenimiento de hepatocitos, SingleQuots, 1 kit

resh Human Hepatocytes Triangle Research Laboratories (TRL), now part of Lonza, provides fresh human hepatocytes isolated from whole and resected liver tissues. The availability of these tissues is difficult to predict. If you would like to be notified of fresh human hepatocyte isolations, please sign up for our FreshAlert list. Primary fresh human hepatocytes can be used for a variety of in vitro applications, including, but not limited to: Metabolism Drug-drug interaction Drug transporter activity Toxicity of drug candidates Cryopreserved Human Hepatocytes Every lot of human cryopreserved hepatocytes is characterized for post-thaw viability and yield, plateability (adherence to a collagen-coated surface), and some combination of Phase I and Phase II drug metabolizing enzyme activities, inducibility, and uptake and efflux transporter activity—documented in a certificate of analysis. We have a wide selection of lots that can be used for a variety of applications, including, but not limited to: Drug metabolizing enzyme activity (stability, clearance, species comparison, metabolite profiling and ID) Suspension drug transporter uptake Time-dependent metabolism (plated assay for low-clearance compounds) CYP450 Induction (mRNA and activity) Plated drug transporter assays (uptake and efflux) Toxicity assays Request TRL's cryopreserved hepatocyte inventory. All suspension qualified human cryopreserved hepatocytes are characterized for CYP450 and Phase II drug-metabolizing enzyme activity. Both single donor and pooled human cryopreserved hepatocytes can be used for a variety of applications including metabolic stability, intrinsic clearance, metabolite ID, metabolite profiling, species comparison studies, and uptake transporter studies.